Fenbendazole and Prostate Cancer: Efficacy and Dosage

J

Jhetzul

Member
I do know that fenbendazole is a broad-spectrum benzimidazole anthelmintic which is used for treating gastrointestinal parasites such as roundworms, whipworms, and giardia. In simple words, it helps in deworming cats and dogs.

But few friends of mine have been talking about it being used for prostate cancer. I do not believe it. I mean, is it possible for a dewormer to turn into a medication for prostate cancer. How far can one go to make fun of others?

Now if it is possible, then what will be the dosage?
 
carmelo

carmelo

Member
Yes, it is possible. A study conducted in 2006 did show that fenbendazole, when used in combination with supplemental vitamins, did inhibit the progress of specific types of tumor cells, including prostate cancer.
 
Gregory

Gregory

Member
I do not think fenbendazole, purely for cancer treatment, has hit the market yet. But a report by the European Medical Agency stated that humans could tolerate fenbendazole after oral exposure of taking 2000mg/person. The treatment is 500mg/person taken consecutively for 10 days.
 
ItsRichard

ItsRichard

Member
I mean, is it possible for a dewormer to turn into a medication for prostate cancer.

Yes. Researchers have found that drugs like fenbendazole do reactivate p53, aka Guardian of Genome. p53 plays the role of tumor suppressors, and it has been found to inhibit certain types of cancer like NSCLC (Non-Small Cell Lung Cancer Cell), lymphomas, glioblastoma, prostate cancer as well as taxane-resistant prostate cancer cells.

There was also an article in Nature in 2018 which stated that fenbendazole has shown to act as a new microtubule destabilizing agent that impacted different cellular pathways leading to the effective elimination of cancerous cells.

Now if it is possible, then what will be the dosage?

I do not think fenbendazole that explicitly targets cancer cells has yet been released in the market. IMO, it will take some time.
 

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M

Marcel

Member
More than fenbendazole, I think niclosamide (tapeworm medication) has better efficacy as an off-label cancer medication.

I know many people, particularly wholistic believers, will not believe it. However, denying the fact that there is a metabolic component in cancer that can be addressed by diet, supplementation, and using off-label drugs like Metformin is not a prudent thing to do.
 
J

jumbo

Member
I have been diagnosed with PC for the last 10 months with a PSA of 10.4. My scans suggested that cancer had spread deep.

My oncologist started diphereline injection. I have been on it for 5 months now. My doctor also started me on fenbenz 444 mg (222mg 2 times) since February 2020. The PSA dropped to 1.3, but the doctor is refusing to believe that this was due to fenbenz. He is insisting on me pursuing radiation.
 

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Potter

Potter

Member
I think fenbendazole will be particularly useful as an anticancer drug because of its ability to inhibit cell division.

As one might know, cancerous cells love dividing uncontrollably. If we inhibit the cell division thereby restricting the division of cancer cells, it will result in them dying. This is why we use vinblastine in chemotherapy.

Fenbendazole binds tightly to parasite tubulin, thereby inhibiting the growth of the parasite. There is also biochemical evidence that it binds to DNA and might make it more susceptible to breaking up as a result of radiation. So fenbendazole can be used as a part of chemotherapy and radiation regimen.
 
M

mehki1980

Member
I have been taking fenbenz – 222mg daily twice 4 days on, 3 days off. Thanks to the dose, my PSA has reduced drastically. We were planning for prostatectomy, but seeing the progress, my doctor has put it off. Fenbenz has been helping big time.
 
C

courtney mitch

Member
More than fenbendazole, I think niclosamide (tapeworm medication) has better efficacy as an off-label cancer medication.

I don’t think so. Niclosamide’s oral bioavailability is extremely poor. Also, a phase-1 trial that was focusing on the use of larger doses to aid castration resistance was canceled due to toxicities from using high doses.

People might say that this trial was supposed to fail because this drug is cheaper, and using this as a cancer drug will pinch big pharma companies. One is free to draw his/her conclusion
 
C

Curious-journey

New member
I have been taking fenbenz – 222mg daily twice 4 days on, 3 days off. Thanks to the dose, my PSA has reduced drastically. We were planning for prostatectomy, but seeing the progress, my doctor has put it off. Fenbenz has been helping big time.
Is this a regular mainstream doc or oncologist that prescribed fenbenz for you? Also, how long did you stay on the fenbenz and has your PSA stayed low?
 
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